Abstract: Structural hole and network closure structure are two typical structures of industrial cluster, whose main features have influence on upgrading knowledge of cluster enterprises. Through case studies, we choose the two knowledge upgrading of Sichuan Province Eagle Textile Co., Ltd. as the research object, and the research results show that: firstly, in different stages of development of enterprises, industrial cluster’s network structure characteristics show different tendencies; secondly, it is beneficial to improve the overall efficiency of cluster enterprise knowledge upgrading to reasonably coordinate the conflict of structural holes and network closure structure; finally, the knowledge search of cluster enterprises cannot ignore the impact of network closure structure’s feature.