Abstract: In the Internet era of rapid development, the cultivation of interdisciplinary talents has become the trend and the direction of colleges talent cultivation. Based on the domestic and foreign research status, this paper uses the symbiosis theory to discuss symbiotic relationship among colleges, enterprises, and government in the process of university interdisciplinary talents cultivation and mechanism. In addition, University of Electronic Science and Technology of China is taken as an example to explain the mechanism of symbiotic system, which provides reference and suggestions for university interdisciplinary talents cultivation especially for research universities.