Abstract: Breakthrough technology innovation is defined as the direction of leading the development of technology and industry, but also the country to enhance comprehensive national strength, to achieve the key means to post development. As a new form of innovation, how to play the dynamic mechanism of the dynamic mechanism, and how to play the synergy effect between the elements is still lack of consensus conclusion. On the basis of the existing literature, this paper analyzes the dynamic factors of breakthrough technology innovation from the perspective of technology, market and policy, according to the characteristics of the breakthrough technology innovation. And combined with the collaborative innovation theory, the concept model of synergy effect of breakthrough technology innovation dynamic factors was constructed between technology and market, when the policy driven is supported. Finally, taking the development of China’s intelligent vehicle as an example, a case study is conducted to provide reference for the enterprise to implement breakthrough technology innovation.