Abstract: Under the background of big data era, compound innovative talent cultivation model should be reformed. University collaborative innovation can realize the cooperation of industry, university and research, and exploring the innovative talents training mode under the mechanism will effectively improve the comprehensive quality of college students. As the characteristic university of the information industry, University of Electronic Science and technology of China (UESTC), taking into account the needs of the times and their own characteristics, had found compound innovative talent cultivation model in the perspective of university collaborative innovation. Through the following measures, UESTC had promoted the development of talent model: establishing experiment course of compound cultivation through subjects fusion, building collaborative innovation center by combining teaching and research, and participating in the business plan competition through school-enterprise cooperation.