Abstract: Innovation and entrepreneurship education is one of the key tasks of China’s higher education reforms in the future, and it is also an important measure to respond positively to the national public " Mass Innovation and Entrepreneurship”. This paper takes Nanyang Technological University (NTU) in Singapore as an example, makes a comparison between NTU and Chinese universities in the innovation and entrepreneurship education, and finds out the shortcomings of innovation and entrepreneurship education in Chinese universities currently. Then, combining with these characteristics and distinctives of NTU, establishing innovation and entrepreneurship education ecosystem, virtuous circle innovation and entrepreneurship education ecosystem, and active innovation and entrepreneurship education ecosystem learning ecosystem are proposed to assist the talent-training of innovation and entrepreneurship education ecosystem, so as to provide new ideas and references for deepening education reform in China.