Abstract: Purpose/Significance In the era of scientific and technological innovation, technological entrepreneurship has gradually become the mainstream of entrepreneurial activities. Compared with general teams, technology-based entrepreneurial teams are in a more changeable and complex environment. The impact of team heterogeneity on innovation performance remains to be tested. Design/Methodology Based on the theory of senior management teams, using 192 technology-based entrepreneurial teams as data sources, the impact of the heterogeneity of technology-based entrepreneurial teams on their innovation performance was tested. Findings/Conclusions The study found that: gender heterogeneity, age heterogeneity, industry heterogeneity, and functional heterogeneity of technological entrepreneurial teams have a significant positive impact on innovation performance. Team size positively regulates gender heterogeneity and age heterogeneity, and has a positive effect on innovation performance. Team communication is positively regulating industry experience, functional heterogeneity, and has a positive effect on innovation performance. The research has enriched the related research of technology-based entrepreneurial teams, and has certain theoretical and practical significance.