Abstract: Purpose/SignificanceInnovation and entrepreneurship education in colleges and universities is an effective way to improve the quality and quantity supply of entrepreneurs. Integrating the concept of sustainable development into the innovation and entrepreneurship education in colleges and universities is an urgent problem to be solved at present. Design/MethodologyIn the context of cross-disciplinary teaching, the course “Innovative Thinking and Innovative Methods” is designed and implemented by the case study method in combination with sustainable development and learning theory. Findings/Conclusions By making the detailed learning objectives clear and evaluating them in various ways, the “theory-practice-feedback” system of the “Innovative Thinking and Innovative Methods” course is formed. It provides suggestions for cultivating future “green entrepreneurs” and provides a reference for innovation and entrepreneurship education in colleges and universities.