Abstract: Purpose/Significance With the rapid development of the digital economy, this paper analyzes the spatial characteristics of the new infrastructure construction in the Yangtze River Economic Belt from the perspective of spatial-temporal differentiation, and grasps the new infrastructure construction in the Yangtze River Economic Belt from different dimensions. It has important guiding significance for the next step of optimizing the spatial layout of new infrastructure construction and implementing precise policies in the Yangtze River Economic Belt. Design/Methodology This paper investigates the spatial-temporal differentiation characteristics of new infrastructure construction in the Yangtze River Economic Belt through data comparison and spatial statistical methods. Conclusions/Findings There are differences in the direction of promoting new infrastructure construction in different regions of the Yangtze River Economic Belt. And different types of new infrastructure construction are different, each region should make trade-offs based on its own location characteristics and identify its advantages.