Abstract: The long-term and medium-term technology planning of our government guidelines from 2006 to 2020 explicitly demand that the key work of science and technology should be focusing on people's livelihood science and technology. This paper is based on the analysis of the relationship between the actual needs of the city developments in Chengdu and the status of university’s science and technology research in Chengdu, to discuss the key areas of the livelihood science and technology development of Chengdu in the future. This paper argues that the key areas of the people's livelihood science and technology should be ecological environmental technology, town construction and energy conservation technology, population health and public safety technology, etc