Abstract: Many new subjects about new media of university students’ entrepreneurship and employment are advanced with the rapid development of new media cultures. This thesis analyzes the characteristics of new media cultures which include integration, sociality, the autonomy of subject consciousness, and their role in effecting entrepreneurship and employment of university students. Then it proposes systematic factors which can establish an optimized and integrated new media of university students’ entrepreneurship and employment, innovate constructive communication systems of new media of university students’ entrepreneurship and employment, and reconstruct social relationship network of new media of university students’ entrepreneurship and employment.