Abstract: The special academic zone, as a new system exploration and practice, is built to strengthen the personnel training and the basic research in some domestic universities recently by learning the success experience of world first classic universities. Constructing the special academic zone is one of the useful ways to increase the academy level of a university. In this paper, the problems on the running system of domestic universities are analyzed briefly. Based on the study of the advanced human system of California Institute of Technology, the definition and the characteristics of the special academic zone are summarized. Four special academic zones with their related running systems in four domestic universities are introduced respectively. Some suggestions on the construction of the academic special zone are put forward at last.