Abstract: Purpose/Significance Meaning Ensuring the safety and health of the people is a major task of the Chinese Communist Party in governing the country. Design/Methodology Since the founding of PRC, China has basically formed a relatively complete epidemic prevention and government system through three stages of “preliminary exploration, perfect development and mature self-confidence”.With the change of national governance and the background of the times, the mode, means and space of epidemic prevention and control in China have changed accordingly. Findings/Conclusions Practice has proved that to win the epidemic prevention and epidemic prevention campaign, we must adhere to the party’s leadership and stimulate the vanguard role of the majority of party members, improve the public health emergency mechanism, unite social forces and unite all forces that can be united, ignore the ideological barriers and build a community of human destiny.