Abstract: Purpose/Significance Along with the convenience brought by the rapid development of artificial intelligence generates widely concerns on the de-humanization hazard. Design/Methodology First of all, moral hazard in AI engineering is analyzed from four perspectives, namely, the technology, interest, responsibility, and environment. If the hazard is not prevented and controlled, it may run contrary to the buildup of human safety, health, and well-being, which are the original purpose of AI development. Secondly, through the classification and comparative analysis of the Asilomar AI Principles and the EU’ Ethics Guidelines for Trustworthy AI, this paper elaborates the importance of three basic principles of engineering ethics to the development of AI technology and ethical research, thereby revealing the scientific path for the development and improvement of ethics principles. Findings/Conclusions Finally, this paper puts forward some suggestions on the people-oriented sustainable development of artificial intelligence, which are of important referential value for stakeholders in AI engineering lifecycle.