Abstract: The leap of artificial intelligence from a “computational tool” to a “generative agent” has triggered a fundamental crisis in the traditional epistemological framework of “subject-object” dualism. To grasp the philosophical essence of human-machine relations in the age of intelligence, the concept of “Human-AI Interaction” is proposed. Distinct from engineered human-machine collaboration, biological human-machine symbiosis, and idealized human-machine fusion, Human-AI Interaction is neither a mere imitation of intersubjectivity nor a mechanical extension of object-relatedness; rather, it constitutes a unique form of inter-ness. Unfolding across functional, embodied, and hermeneutic dimensions, this concept offers philosophical guidance and a novel pathway for understanding and navigating human-machine relations in the intelligent era, transcending both instrumental rationality and anthropocentrism.