Abstract: The development of people’s livelihood science and technology is priority work of the science and technologies in The 12th Five-Year Plan and the Universities have the responsibility of developing it. This article discusses the transformation path and countermeasures of People’s livelihood science and technology by taking Chengdu’s Universities as the main body of this research. Through deep analysis on present situation and problems of transformation of people’s livelihood science and technology in Chengdu’s universities, and combination with innovation diffusion theory, the paper gives the following countermeasure: 1. developing the people's livelihood science and technology based on the actual demands; 2. constructing an achievements transformation platform of integration of enterprises, campuses and research institutes; 3. strengthening and perfecting the functions of universities research management departments; 4. constructing a financing system of achievements transformation; 6. establishing an organization of special technologies achievements transformation; 7. realizing the cooperation of universities and cooperations