Abstract: Purpose/Significance The diversified cognition and behavior differences of social groups on epidemic control increase the difficulty of epidemic control. Design/Methodology By evaluating social groups’ scientific cognition, risk identification, psychological quality, safety behavior, humanity towards the outbreak of the 2019-nCoV, this paper analyzes the weakness of the anti-epidemic ability of the current social groups.Findings/Conclusions Constructs the anti-epidemic guiding mechanism from three aspects of information guidance, psychological assistance and behavior restriction, to further work against the 2019-nCoV epidemic.